July 03, 2012Posted by Francesco Abate


Bellerophontes is a fully automated framework for the detection of novel fusion transcripts in paired end RNA-Seq data.

Bellerophontes detects putative fusion genes by searching those reads that discordantly matches on different genes. Then, the tool applies several modular filters in order to select those fused genes matching an accurate gene fusion model based on experimental evidences reported in recent literature. Bellerophontes runs on top of TopHat and Cufflinks tools (developed by Trapnell et al.). The analysis is based on the results of TopHat alignment and Cufflinks transcript isoform detection.

Bellerophontes is the result of conjunct research efforts of EDA Group of Politecnico of Turin and Massimo Delledonne Lab of University of Verona.